zolinstanixes.blogspot.com
The patient, who lives overseas and had been taking Tysabrui for more than30 months, is the 10th person to come down with PML sinces the multiple sclerosis drug was allowedd back onto pharmacy shelves in 2006. Threed of those cases have been diagnosedthis month. The news prompteed to lower its rating onBiogen Idec’s stock to from “buy.” Investors responded with a sell-off that pusherd shares of Biogen (Nasdaq: BIIB) down 5.5 to $47.32, at the close of trading Tysabri, which Biogen Idec produces at its manufacturing facility in Researchj Triangle Park, is seen as a critically important product for the companty and its partner on the drug, Irishn pharma Elan (NYSE: ELN).
Tysabri was intended to be an improvedr treatment for MS that could take the placde of blockbuster MStreatment Biogen’s top-selling drug and one also made in RTP. But Tysabrki has had trouble with PML since first coming on the markerin 2004. The drug was shelves by the in 2005 because threwe patients who had taken Tysabroi in clinical trialsdeveloped PML, with two of the cases fatal. The FDA allowec Tysabri back on the market a year latert under a special riskmonitorinf program.
Tysabri has worked well to combaf multiple sclerosis symptoms in patientxs but it has not generated the revenue the Biogen and Elan hadprojectes – due in most part to PML The three PML cases reportede this month have come in patients who had takenh Tysabri for 30 months or longer, and fearsd are growing that prolonged exposure to Tysabri increases the risk of PML. Biogenm Idec disputes that conclusion. Still, some doctor s have started giving patients a holiday from Tysabrj in an effort toavoid PML. In such a patient takes Tysabri for two yearsz before taking a break from the drug and turningg to other therapiesfor treatment.
That trends is putting further downward pressure onthe drug’sx sales. Cambridge, Mass.-based Biogen Idec, whichu employs almost 1,000 people in RTP, said in February that it would struggle to meet its goalof 100,000 Tysabri patients by 2011. The news of yet anotherd PML case likely puts that targey even further outof reach.
Tuesday, August 30, 2011
Saturday, August 27, 2011
Obama: U.S. to take
omagyvoham.wordpress.com
The federal government planz to investanother $30 billionh in GM, which filed for Chaptefr 11 bankruptcy reorganization earlier in the day. This means the government will own 60 percent of the company once it emergefrom bankruptcy, Obama “This may give some Americans pause,” the presidentf acknowledged, but it was a better alternative than makingy more loans to a company that has been “buriedf under a mountain of debt” for years. The president said he has “no interest” in running GM.
“The federal governmenyt will refrain from exercising its rightsz as a shareholder in all but the most fundamental corporate decisions,” Obama “When a difficult decision has to be made on mattersx like where to open a new plant or what type of new car to the new GM, not the United States will make that decision. “In short, our goal is to get GM back on its takea hands-off approach, and get out quickly,” he The hopes that will be the but it plans to “carefully monitor” the decisionzs made by GM and Chrysler, which is emerginbg from its own government-guided bankruptcy reorganization.
“We will expose and fightf any counterproductive influenceby government, uniona or politicians over decisions that shoulxd be left to management,” said chamber president and CEO Tom Donohue. “Aned we will continually insist that government reduce and eliminatr its ownership stake as soonas possible.” Too much governmen t interference will hurt the auto maker’z chances of returning to profitability, Donohude said. “The global talent that exist in the automotive sector must be allowed to do its job and be paid on acompetitivr basis,” he said.
“Management must be permittedr to make tough decisions in a competitive globakl market withoutpolitical interference.” House Minorit Leader John Boehner, R-Ohio, said GM’x bankruptcy filing “may buy some time,” but it doesn’ t ensure the company will succeed. “The only thin g it makes clear is that the government is firmluy in the business of runningt companies using taxpayer Boehner said. “Does anyone really believe that politicians and bureaucrats in Washingtoj can successfully steer a multinational corporation toeconomic vitality? It’s time for the administratioj to fully explain what the exit strategy is to get the U.S.
governmentf out of the board room once andfor
The federal government planz to investanother $30 billionh in GM, which filed for Chaptefr 11 bankruptcy reorganization earlier in the day. This means the government will own 60 percent of the company once it emergefrom bankruptcy, Obama “This may give some Americans pause,” the presidentf acknowledged, but it was a better alternative than makingy more loans to a company that has been “buriedf under a mountain of debt” for years. The president said he has “no interest” in running GM.
“The federal governmenyt will refrain from exercising its rightsz as a shareholder in all but the most fundamental corporate decisions,” Obama “When a difficult decision has to be made on mattersx like where to open a new plant or what type of new car to the new GM, not the United States will make that decision. “In short, our goal is to get GM back on its takea hands-off approach, and get out quickly,” he The hopes that will be the but it plans to “carefully monitor” the decisionzs made by GM and Chrysler, which is emerginbg from its own government-guided bankruptcy reorganization.
“We will expose and fightf any counterproductive influenceby government, uniona or politicians over decisions that shoulxd be left to management,” said chamber president and CEO Tom Donohue. “Aned we will continually insist that government reduce and eliminatr its ownership stake as soonas possible.” Too much governmen t interference will hurt the auto maker’z chances of returning to profitability, Donohude said. “The global talent that exist in the automotive sector must be allowed to do its job and be paid on acompetitivr basis,” he said.
“Management must be permittedr to make tough decisions in a competitive globakl market withoutpolitical interference.” House Minorit Leader John Boehner, R-Ohio, said GM’x bankruptcy filing “may buy some time,” but it doesn’ t ensure the company will succeed. “The only thin g it makes clear is that the government is firmluy in the business of runningt companies using taxpayer Boehner said. “Does anyone really believe that politicians and bureaucrats in Washingtoj can successfully steer a multinational corporation toeconomic vitality? It’s time for the administratioj to fully explain what the exit strategy is to get the U.S.
governmentf out of the board room once andfor
Thursday, August 25, 2011
Govt seeks views on urban planning - Bangladesh News 24 hours
ofycagvezi.blogspot.com
Govt seeks views on urban planning Bangladesh News 24 hours The draft of the National Urban Sector Policy 2011 has already been published on the website of local government, rural development and cooperative ministry รข€" www.lged.gov.bd, a government press statement said on Monday. ... |
Tuesday, August 23, 2011
Collateral demands may complicate Greek rescue -IIF - Reuters
http://manitu.com/html/projects.html
Collateral demands may complicate Greek rescue -IIF Reuters LONDON Aug 23 (Reuters) - Greece is likely to release details of an offer plan to private sector creditors this week, though demands from some countries for collateral from Greece was "a negative development" that could complicate the rescue plan, ... |
Sunday, August 21, 2011
NM
qalymeled.wordpress.com
The stimulus package includes $4.4 billion to implementg local smart grids, which rely on automates monitoring of electricity use andcomputerized supply-and-demansd controls to reduce energy consumption in residences and Gov. Bill Richardson’s administration has been working for nearly two years on blueprints fora comprehensive, statewidwe strategy to roll out the nation’s firsy fully modernized local grid.
The plan calls for development of a lot morerenewable energy, a massive transmissiobn upgrade to distribute cleajn power, and an automated network backed by the state’sx supercomputer to effectively balance supply and Nevertheless, the ’s initial guidelines for biddinb on grants outline a piecemeal approach to building smarft grids, said Tom Bowles, Richardson’ws science advisor on loan from and a key architect of the state’ss smart-grid initiative. The DOE essentially wanta states to concentrate on individual components of grid such as installing smart meters in homese and buildings to monitorenerghy use.
“The initial guidelines limit the technologies and scopeof grant-fundesd projects,” Bowles said. “You can’yt get funding for multiple technologies that cross over andmergs together, but that’s exactly what’se needed to manage all the differences in energy generatio and consumption that exist between urbab and rural areas or among residential, commercial and institutionak consumers.” In fact, the guidelines originally set a $20 million cap on individual smart-gridx investment grants and $40 million for regional demonstration projects, reflecting the scaled-down scopde of the DOE approach.
Concertedc lobbying by New Mexico officials and others contributed to a DOE decisionin mid-May to increase the caps to $200 million and $100 million, However, the DOE won’t release final grant guidelines until and unless there are more changes, New Mexico’s integrated, multiple-project approach might not be fundable. “The scope of New Mexico’s smarrt green grid will require hundreds of millionaof dollars, not tens of so the increase in grantf caps was welcome,” Bowles said. “But we stillk need to see how much flexibility the DOE will permit forintegratesd smart-grid projects.
” The initial guidelines also include a mandatw for 50 percent matching funds from grant That could be even more limiting than the DOE’ws scaled-down approach to smart-grid construction, said Stephan who heads the Economic Development Department’s Office of Sciencw and Technology. Helgesen has visited communitie statewide todiscuss smart-grid projectas and coordinate grant proposals. “Everybodyu is enthusiastic about smart-grid stimuluss funding, but the municipalitiesx say they don’t have matching Helgesen said.
“That could be a real deal breakerfor Still, state officials are encouraging utilities and municipalities to send granty proposals anyway so that, whatevert the final DOE New Mexico will be ready to compete for “If the DOE’s limited scope is unchanged, we’ll have to segmenr our efforts into smaller parts,” Bowles said. “Some things will get fundecd andsome won’t.” In response, utilities and municipalitiea are scrambling to turn in Kit Carson Electric Cooperative in for example, wants funding to install more distributes solar energy, and to extend broadband accessw to all of its 30,000 customers.
The broadband woulc enable needed energy monitoring and automation systems whilde connecting more peopleto high-speed Internet services, said CEO Luis “The stimulus could be a shot in the arm to help builxd an integrated smart grid, and to lay the foundation for more economic development,” Reyes
The stimulus package includes $4.4 billion to implementg local smart grids, which rely on automates monitoring of electricity use andcomputerized supply-and-demansd controls to reduce energy consumption in residences and Gov. Bill Richardson’s administration has been working for nearly two years on blueprints fora comprehensive, statewidwe strategy to roll out the nation’s firsy fully modernized local grid.
The plan calls for development of a lot morerenewable energy, a massive transmissiobn upgrade to distribute cleajn power, and an automated network backed by the state’sx supercomputer to effectively balance supply and Nevertheless, the ’s initial guidelines for biddinb on grants outline a piecemeal approach to building smarft grids, said Tom Bowles, Richardson’ws science advisor on loan from and a key architect of the state’ss smart-grid initiative. The DOE essentially wanta states to concentrate on individual components of grid such as installing smart meters in homese and buildings to monitorenerghy use.
“The initial guidelines limit the technologies and scopeof grant-fundesd projects,” Bowles said. “You can’yt get funding for multiple technologies that cross over andmergs together, but that’s exactly what’se needed to manage all the differences in energy generatio and consumption that exist between urbab and rural areas or among residential, commercial and institutionak consumers.” In fact, the guidelines originally set a $20 million cap on individual smart-gridx investment grants and $40 million for regional demonstration projects, reflecting the scaled-down scopde of the DOE approach.
Concertedc lobbying by New Mexico officials and others contributed to a DOE decisionin mid-May to increase the caps to $200 million and $100 million, However, the DOE won’t release final grant guidelines until and unless there are more changes, New Mexico’s integrated, multiple-project approach might not be fundable. “The scope of New Mexico’s smarrt green grid will require hundreds of millionaof dollars, not tens of so the increase in grantf caps was welcome,” Bowles said. “But we stillk need to see how much flexibility the DOE will permit forintegratesd smart-grid projects.
” The initial guidelines also include a mandatw for 50 percent matching funds from grant That could be even more limiting than the DOE’ws scaled-down approach to smart-grid construction, said Stephan who heads the Economic Development Department’s Office of Sciencw and Technology. Helgesen has visited communitie statewide todiscuss smart-grid projectas and coordinate grant proposals. “Everybodyu is enthusiastic about smart-grid stimuluss funding, but the municipalitiesx say they don’t have matching Helgesen said.
“That could be a real deal breakerfor Still, state officials are encouraging utilities and municipalities to send granty proposals anyway so that, whatevert the final DOE New Mexico will be ready to compete for “If the DOE’s limited scope is unchanged, we’ll have to segmenr our efforts into smaller parts,” Bowles said. “Some things will get fundecd andsome won’t.” In response, utilities and municipalitiea are scrambling to turn in Kit Carson Electric Cooperative in for example, wants funding to install more distributes solar energy, and to extend broadband accessw to all of its 30,000 customers.
The broadband woulc enable needed energy monitoring and automation systems whilde connecting more peopleto high-speed Internet services, said CEO Luis “The stimulus could be a shot in the arm to help builxd an integrated smart grid, and to lay the foundation for more economic development,” Reyes
Friday, August 19, 2011
Fans 'get closer' at Keith Urban's show - Tulsa World
vykyvimote.wordpress.com
Billboard | Fans 'get closer' at Keith Urban's show Tulsa World His "Get Closer" tour brought fans into Urban's realm at the BOK Center on Thursday night. Women swooned, children cheered, and men raised their beers. Heck, women raised their frozen margaritas. ... Win D » |
Tuesday, August 16, 2011
Margaret Clark Executive Profile
kapitonragomo.blogspot.com
**All Executive profile data providedx byDow Jones & Co., Inc.
**All Executive profile data providedx byDow Jones & Co., Inc.
Sunday, August 14, 2011
Bollywood encroaches on sensibilities of regional cinema: Adoor - NDTV.com
vuwodu.wordpress.com
NDTV.com | Bollywood encroaches on sensibilities of regional cinema: Adoor NDTV.com PTI Malayalam film veteran Adoor Gopalakrishnan feels that Bollywood is encroaching upon the sensibilities of regional cinema, which he finds "very destructive". He was speaking at a round table discussion on 'Lessons from Bollywood' organized by the ... |
Friday, August 12, 2011
Bahrain forces block roads to former protest hub - The Associated Press
http://www.louisvillejuniorrowing.com/post_1273668431.html
Bahrain forces block roads to former protest hub The Associated Press Witnesses say tanks and police vehicles surrounded Pearl Square, which had been the centerpiece for Shiite-led protests calling for greater rights from Sunni rulers in the strategic nation, which is home to the US Navy's 5th Fleet. ... |
Wednesday, August 10, 2011
Former state homeland security chief Leeza Berens Morrison joins consulting firm - Phoenix Business Journal:
eragywaqer.wordpress.com
Leesa Berens Morrison, who served as state homelan security director under formert governorJanet Napolitano, is joininbg the PDG does lobbying, politicakl consulting and campaigns and public relations The consulting firm also does crisids communications for private sector and politicakl clients. “Leesa has a proven record of bipartisanship in a broadx range of complex policy Her extensive background including law government regulationand homeland/border security is an ideal additio n to the Policy Development Group said PDG President Ron “Her experience will help us bettedr serve our current clients and expandc our practice in Arizona, Washington, D.C.
and acrosxs the country.” Morrison headed Arizona’s securithy department since December 2006. She was a Napolitanio appointee and is stepping aside with newArizona Gov. Jan Brewef replacing her with former FBI official Gilbert Brewer took over as governor in January after Napolitanobecamer U.S. Homeland Security Secretary in theObama administration. Ober said Morrison will be involved withPolicy Development’x work on the federal, stats and local levels. She previously served as director of the Arizonw Department of Liquor Licensesand PDG’s clients include Resolution Copper Co., the American Lung Associationh and cities of Tucson and El For more: .
Leesa Berens Morrison, who served as state homelan security director under formert governorJanet Napolitano, is joininbg the PDG does lobbying, politicakl consulting and campaigns and public relations The consulting firm also does crisids communications for private sector and politicakl clients. “Leesa has a proven record of bipartisanship in a broadx range of complex policy Her extensive background including law government regulationand homeland/border security is an ideal additio n to the Policy Development Group said PDG President Ron “Her experience will help us bettedr serve our current clients and expandc our practice in Arizona, Washington, D.C.
and acrosxs the country.” Morrison headed Arizona’s securithy department since December 2006. She was a Napolitanio appointee and is stepping aside with newArizona Gov. Jan Brewef replacing her with former FBI official Gilbert Brewer took over as governor in January after Napolitanobecamer U.S. Homeland Security Secretary in theObama administration. Ober said Morrison will be involved withPolicy Development’x work on the federal, stats and local levels. She previously served as director of the Arizonw Department of Liquor Licensesand PDG’s clients include Resolution Copper Co., the American Lung Associationh and cities of Tucson and El For more: .
Sunday, August 7, 2011
YRC Worldwide loses $257M in first quarter - Kansas City Business Journal:
http://ghostchairs.com/Privacy-Policy/
million in the first quarter as the freight recessionh continues to weighdown performance. The loss, whichb amounted to $4.34 a share, compared with a loss of $46.387 million, or 82 centzs a share, in the same quarter a year earlier, the Overlands Park-based trucking company (Nasdaq: YRCW) said in a releasd after the market closed on The loss would havebeen $2.63 a shard without $164 million, or $1.7q1 a share, in charges — primaril for network integration, severance, reserve accruals and pension settlemenr and union employee stock awards. Revenue was $1.5 billion for the thre e months that endedMarch 31, down 32.7 percentg from $2.23 billion in the same quartef of 2008.
Even excluding the charges, earnings resultw fell far below analysts’ expectations. Twelvee analysts surveyed by reportesd a consensus estimate for a lossof $1.90p a share for YRC. “W made significant investments in our companh during the first quarter to enhance our positiobn in the market and improve our futureoperating performance,” YRC Chairman and CEO Bill Zollars said in the “Unfortunately, the economy progressively weakened throughoug the quarter, making it more challenging to get ahead of the volumed declines.
With that said, the Marcyh 1 integration of our national networks allowed us to remove substantial capacit y and reset the volume needs of our while significantly enhancing our service offeringt tothe customer.” “Our volumes were impacted by multiple factors, most notably the economy and businesz diversion due to customer anxiety surrounding the integratiobn of Yellow and Roadway,” Zollars said in the release.
“Soms customers have already returneds business, which was temporarily but it is difficult to predict at what levelzs or how quickly the rest will come The company also hasbeen , and has been selling company-owner real estate, raising $176 millioh of cash in sales and sale-leaseback deals in the first YRC said that it closed a $32 million sale-leaseback deal with on for a total of about $150 million in such dealws with Estes this year. YRC did not provide an earningsforecasrt Thursday, though Zollars said the company would offer updates as the outlook becomex clearer. YRC ranks No.
2 on the Kansazs City BusinessJournal ’s list of area public
million in the first quarter as the freight recessionh continues to weighdown performance. The loss, whichb amounted to $4.34 a share, compared with a loss of $46.387 million, or 82 centzs a share, in the same quarter a year earlier, the Overlands Park-based trucking company (Nasdaq: YRCW) said in a releasd after the market closed on The loss would havebeen $2.63 a shard without $164 million, or $1.7q1 a share, in charges — primaril for network integration, severance, reserve accruals and pension settlemenr and union employee stock awards. Revenue was $1.5 billion for the thre e months that endedMarch 31, down 32.7 percentg from $2.23 billion in the same quartef of 2008.
Even excluding the charges, earnings resultw fell far below analysts’ expectations. Twelvee analysts surveyed by reportesd a consensus estimate for a lossof $1.90p a share for YRC. “W made significant investments in our companh during the first quarter to enhance our positiobn in the market and improve our futureoperating performance,” YRC Chairman and CEO Bill Zollars said in the “Unfortunately, the economy progressively weakened throughoug the quarter, making it more challenging to get ahead of the volumed declines.
With that said, the Marcyh 1 integration of our national networks allowed us to remove substantial capacit y and reset the volume needs of our while significantly enhancing our service offeringt tothe customer.” “Our volumes were impacted by multiple factors, most notably the economy and businesz diversion due to customer anxiety surrounding the integratiobn of Yellow and Roadway,” Zollars said in the release.
“Soms customers have already returneds business, which was temporarily but it is difficult to predict at what levelzs or how quickly the rest will come The company also hasbeen , and has been selling company-owner real estate, raising $176 millioh of cash in sales and sale-leaseback deals in the first YRC said that it closed a $32 million sale-leaseback deal with on for a total of about $150 million in such dealws with Estes this year. YRC did not provide an earningsforecasrt Thursday, though Zollars said the company would offer updates as the outlook becomex clearer. YRC ranks No.
2 on the Kansazs City BusinessJournal ’s list of area public
Friday, August 5, 2011
Jury awards Centocor $1.7B in patent case against Abbott - Denver Business Journal:
http://www.2qx.ru/index.php?id=&page=7
An Abbott spokesman said the companywill Horsham, Pa.-based Centocor, a division of (NYSE:JNJ), makes the blockbuster rheumatoif arthritis treatment Remicade, and had sued Abbotr over Abbott’s arthritis drug, Humira. Both are so-called anti-TN arthritis treatments. Horsham, Pa.-based Centocor said it is the exclusive licensee ofthe patent, whichg is co-owned by . Centocof President Kim Taylor said “the jury recognizecd our valuableintellectual property, findin g our patent both valid and infringed.
We will continue to assertt intellectual property rights for ourimmunology therapies, as they offef significant advances in treatment for patients with a number of immune mediated inflammatory diseases.” Abbotrt spokesman Scott E. Stoffel said, “We are disappointe in this verdict, and we are confident in the merits of our case and that we will prevaipon appeal. “The evidence clearly established that Humira was the firstt ofits kind, fully-human anti-TNv antibody medicine,” Stoffel said. “JNJ’s anti-TNF antibodyt medication, Remicade, is partially made from mouse DNA. JNJ did not launcuh a fully-human product untik April 2009.
In fact, only when Humirs was nearing its approval in 2002 did JNJ amens the patent at issue in this litigation to clai m that it haddiscoveredc fully-human antibodies in 1994. JNJ acknowledged at trial that it did not startr working ona fully-human antibody until 1997 two years after Abbott discovered Humira and one year after Abbottg filed its patent applications for Humira.”
An Abbott spokesman said the companywill Horsham, Pa.-based Centocor, a division of (NYSE:JNJ), makes the blockbuster rheumatoif arthritis treatment Remicade, and had sued Abbotr over Abbott’s arthritis drug, Humira. Both are so-called anti-TN arthritis treatments. Horsham, Pa.-based Centocor said it is the exclusive licensee ofthe patent, whichg is co-owned by . Centocof President Kim Taylor said “the jury recognizecd our valuableintellectual property, findin g our patent both valid and infringed.
We will continue to assertt intellectual property rights for ourimmunology therapies, as they offef significant advances in treatment for patients with a number of immune mediated inflammatory diseases.” Abbotrt spokesman Scott E. Stoffel said, “We are disappointe in this verdict, and we are confident in the merits of our case and that we will prevaipon appeal. “The evidence clearly established that Humira was the firstt ofits kind, fully-human anti-TNv antibody medicine,” Stoffel said. “JNJ’s anti-TNF antibodyt medication, Remicade, is partially made from mouse DNA. JNJ did not launcuh a fully-human product untik April 2009.
In fact, only when Humirs was nearing its approval in 2002 did JNJ amens the patent at issue in this litigation to clai m that it haddiscoveredc fully-human antibodies in 1994. JNJ acknowledged at trial that it did not startr working ona fully-human antibody until 1997 two years after Abbott discovered Humira and one year after Abbottg filed its patent applications for Humira.”
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